http://www.permies.com/permaculture-forums/2807_0/cooking-and-food-preservation/agave-nectar-low-gi-or-high-fructose
The recent study folks have been touting as proving HFCS is bad for you, compares pure fructose to pure glucose. I might not be re-stating this correctly, but it seems fructose goes straight to the liver, and doesn't immediately cause blood sugar spiking, but causes blood sugar problems over time and the wrong kind of fat creation, among other significant health risk things. Cane sugar also contains fructose, possibly in comparable ratios as HFCS. According to the article linked above, HFCS is about 55% fructose and agave nectar is 70% fructose. Wow.